Examinations for Sexual Dysfunction in men

Sexual dysfunction can place a significant burden on both mental well-being and relationships. Therefore, it should not be considered a taboo subject. Talk to your doctor about it.

The following questions and examinations can be expected during a medical consultation:

  1. 1. Medical History and Assessment of Symptoms

(Possibly including the partner)

* Duration of diabetes

* Quality of diabetes control

* Presence of diabetes-related complications, particularly neuropathy (nerve damage)

* Signs of circulatory problems

* Coronary artery disease

* History of stroke

* Circulatory disorders affecting the legs

  1. Evaluation of Diabetes Control and Complications

* Quality of diabetes control

* Presence of complications, particularly neuropathy

* Signs of circulatory problems

* Coronary artery disease

* History of stroke

* Circulatory disorders affecting the legs

  1. Medication Review and Questions About Erectile Dysfunction

* Current medications, particularly in relation to erectile dysfunction

* How long has the problem existed?

* Are you in a stable relationship?

* Is sexual intercourse possible, and how often does it occur?

* How frequently did intercourse occur previously?

* Does ejaculation occur?

* Is ejaculation premature?

* Do spontaneous morning erections occur?

  1. Physical Examination

* Assessment of blood circulation in the groin and feet

* Evaluation of nerve function using a reflex hammer and tuning fork

* Examination of the genital organs, if necessary

  1. Hormonal Testing

Hormonal abnormalities can contribute significantly to reduced libido, erectile dysfunction, difficulty achieving orgasm, fatigue, and reduced overall well-being. Blood tests are therefore often performed to identify potentially treatable endocrine causes of sexual dysfunction.

Testosterone

Testosterone is the principal male sex hormone and plays a key role in:

  • Sexual desire (libido)
  • Erectile function
  • Energy levels and vitality
  • Muscle mass and strength
  • Mood and cognitive function

Low testosterone levels (hypogonadism) are more common in men with Type 2 diabetes and obesity. A deficiency may contribute to reduced sexual desire, erectile dysfunction, fatigue, depression, and loss of muscle mass.

Pituitary Hormones (LH and FSH)

The pituitary gland controls testosterone production by releasing:

  • Luteinizing Hormone (LH) – stimulates testosterone production in the testes
  • Follicle-Stimulating Hormone (FSH) – supports sperm production

Measuring LH and FSH helps determine whether low testosterone is caused by:

  • A problem in the testes (primary hypogonadism), or
  • A problem in the pituitary gland or hypothalamus (secondary hypogonadism)

Prolactin

Prolactin is a hormone produced by the pituitary gland.

Elevated prolactin levels can:

  • Suppress testosterone production
  • Reduce sexual desire
  • Cause erectile dysfunction
  • Lead to infertility

Markedly elevated prolactin levels may indicate a pituitary disorder and may require further investigation.

Additional Hormonal Tests (if indicated)

Depending on symptoms and medical history, additional hormones may be evaluated, including:

  • Thyroid hormones (TSH, FT4): thyroid disorders can affect libido, energy levels, and erectile function.
  • Estradiol: elevated levels may contribute to reduced testosterone activity.
  • Cortisol: abnormalities may affect energy levels and sexual function.
  • Sex Hormone-Binding Globulin (SHBG): helps determine the amount of biologically active testosterone.
  1. Specialized Diagnostic Tests

(Performed only when necessary)

These tests are usually reserved for patients in whom the cause of erectile dysfunction remains unclear after the initial assessment or when a vascular cause is suspected.

Intracavernosal Injection and Stimulation Test (ICI Test)

The ICI test ( intracavernosal injection test) evaluates the ability of the penile blood vessels and erectile tissue to produce an erection.

A small amount of a vasoactive medication (usually alprostadil) is injected directly into one of the erectile bodies (corpora cavernosa) of the penis using a very fine needle. The injection is generally well tolerated and causes little discomfort.

The physician then observes:

  • Whether an erection develops
  • How quickly it develops
  • The quality and rigidity of the erection
  • How long it lasts

Interpretation of the Results

Rapid, Firm Erection

  • Suggests normal arterial blood flow
  • Indicates that the erectile tissue is functioning adequately
  • Makes a significant vascular abnormality less likely

Delayed or Weak Erection

  • Suggests reduced arterial inflow
  • May indicate narrowing of the penile arteries due to:
    • Diabetes
    • Atherosclerosis
    • Smoking
    • Cardiovascular disease

No Meaningful Erection

  • May indicate severe vascular impairment
  • May suggest venous leakage (“venogenic erectile dysfunction”), where blood enters the penis but cannot be retained adequately to maintain an erection

Advantages of the ICI Test

The test can help distinguish between:

  • Psychogenic erectile dysfunction
  • Arterial insufficiency
  • Venous leakage
  • Mixed causes

It can also help determine whether treatments such as oral medications, injection therapy, vacuum devices, or surgery are likely to be effective.

Potential Risks

Although generally safe, possible side effects include:

  • Mild pain at the injection site
  • Small bruises
  • Prolonged erection (priapism), which requires prompt medical attention if it lasts more than several hours

Doppler Ultrasound of the Penile Arteries

A penile Doppler ultrasound is often performed together with the ICI test.

After administration of the erection-inducing medication, an ultrasound probe is used to assess blood flow within the penile arteries.

What the Examination Measures

  • Peak arterial blood flow velocity
  • Adequacy of blood supply to the erectile tissue
  • Venous drainage function
  • Structural abnormalities of the penis

What the Results Can Show

The examination can identify:

  • Arterial insufficiency caused by diabetes or atherosclerosis
  • Venous leakage
  • Impaired erectile tissue function
  • Vascular damage resulting from long-standing diabetes

Because erectile dysfunction may be an early sign of generalized vascular disease, abnormal Doppler findings can also indicate an increased risk of cardiovascular disease elsewhere in the body.

Why These Tests Matter

For many men, erectile dysfunction is the first noticeable symptom of diabetes-related nerve or blood vessel damage. A comprehensive evaluation helps determine whether the problem is primarily:

  • Psychological
  • Hormonal
  • Neurological
  • Vascular
  • Medication-related

It can also help determine whether treatments such as oral medications, injection therapy, vacuum devices, or surgery are likely to be effective.