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These crystals form when the uric acid level in the blood becomes too high (hyperuricemia).
The body is then unable to eliminate the excess uric acid sufficiently.
Typical Features
Causes
Treatment
What helps prevent gout attacks?
If you like, I can also explain symptoms, risk factors, or dietary recommendations in more detail.
Typical Features
Causes
Treatment
Preventive Measures
If you’d like, I can also provide detailed explanations of symptoms, risk factors, or nutrition tips.
Cause of Increased Uric Acid
Uric acid is produced from purines through the normal breakdown pathway of purine bases in the body.
How is Purine converted into Uric Acid?
Purine comes from two sources:
The body breaks down purines in several steps:
The enzyme xanthine oxidase converts hypoxanthine into xanthine.
Xanthine oxidase then oxidizes xanthine further into uric acid.
Uric acid is the final end product of purine metabolism in humans.
Why is this important in gout?
Humans lack an enzyme to break down uric acid further.
→ If too much is produced or too little is excreted, levels rise.
→ Uric acid crystallizes and can trigger gout attacks.
In summary
Purine → Hypoxanthine → Xanthine → Uric Acid
(all via the enzyme xanthine oxidase)
Typical Triggers for Gout Attacks
Typical triggers for a gout attack are situations in which uric acid levels suddenly rise or fall—both can lead to crystals forming or being released in the joint.
Here are the most important triggers:
Foods that strongly increase uric acid levels:
Alcohol interferes with the breakdown and excretion of uric acid.
Most risky:
Often, a single evening with heavy drinking can trigger an attack.
Especially:
Fructose increases uric acid production very quickly.
A classic trigger: “holiday gout.”
Less fluid intake = poorer uric acid excretion.
Typical situations:
Especially:
Some medications can trigger gout attacks:
A stressed joint tends to become inflamed.
Most common immediate triggers:
Alcohol, purine-rich foods, sugar/fructose, dehydration, certain medications, and sudden metabolic changes.
List of Foods That Can Trigger Gout Attacks
Below is a clear overview of foods sorted by:
These should be limited or avoided.
Meat & Organ Meats
Fish & Seafood
Alcohol (strong trigger)
Sugar & Fructose
Other triggers
Meat / Fish
Vegetables with moderate purines
(But vegetables rarely trigger gout!)
Drinks
Fruits & Vegetables
Dairy products
Grains & starches
Protein sources
Drinks
Summary
Table of Low-Purine Foods
(Purine-low = <100 mg purines per 100 g)
Low-Purine Foods Table
Category | Examples | Purine content | Suitable for gout? |
Vegetables (very low) | Tomatoes, peppers, zucchini, carrots, cucumber, lettuce, broccoli | 0–30 mg | Very good |
Fruit | Apples, berries, grapes, cherries, pears, melons, oranges | 0–20 mg | Very good |
Potatoes | Potatoes, sweet potatoes | ~10 mg | Very good |
Grains | Rice, pasta, bread, oatmeal, couscous | 0–50 mg | Very good |
Dairy (low-fat) | Milk, yogurt, quark, cottage cheese | 0–15 mg | Very good (lowers uric acid!) |
Cheese | Hard & soft cheeses (e.g., gouda, edam, mozzarella) | minimal | Very good |
Eggs | Eggs | 0 mg | Very good |
Nuts / seeds | Almonds, walnuts, cashews, sunflower seeds | 10–30 mg | Good |
Tofu / soy | Tofu, tempeh | 20–60 mg | Good |
Drinks | Water, coffee, herbal tea | 0 mg | Very good |
Oils / fats | Olive oil, canola oil, butter | 0 mg | Very good |
High-Fructose Fruits (important for gout)
High fructose intake can significantly raise uric acid levels.
High-Fructose Fruits (>5 g fructose per 100 g) — eat only in small amounts
Fruit | Fructose (g/100 g) | Notes |
Apples | 5.9 | Depends on variety |
Pears | 6.2 | Very high fructose |
Mango | 5.7 | Very sweet when ripe |
Watermelon | 3.4–5.0 | Depends on variety |
Grapes | 7–8 | Very high total sugar |
Pineapple | 4.3–5.0 | Medium-high |
Cherries | 6.2 | Despite sugar → gout-friendly |
Figs (fresh) | 4.8–5.0 | — |
Dates (fresh) | 6–7 | Dried dates extremely sugary |
Low-Fructose Fruits (<3 g/100 g) — good for gout
Fruit | Fructose (g/100 g) | Notes |
Strawberries | 2.0 | Very suitable |
Raspberries | 1.5 | Very good |
Blueberries | 3.0 | Borderline, but fine |
Peaches | 1.5–2.0 | Well tolerated |
Apricots | 0.9 | Very low |
Avocado | <0.2 | Almost sugar-free |
Grapefruit | 2.3 | Gout-friendly |
Papaya | 3.0 | Suitable |
Kiwi | 2.2 | Very good |
Lemon / lime | <1 | Very low |
Special cases
Fruit | Note |
Cherries | High in fructose but lower uric acid → good in moderation |
Bananas | Moderate fructose (3–4 g), high total sugar → okay in moderation |
Dried fruit | Very high sugar → avoid |
Short Summary
Table: Medications That Can Trigger Gout Attacks
These medications may worsen gout by reducing uric acid excretion or increasing uric acid levels.
Drug class | Typical agents / examples | Why they increase risk |
Diuretics | Hydrochlorothiazide (HCT), furosemide, torasemide | Reduce uric acid excretion; most important trigger |
Low-dose aspirin (ASA 75–100 mg) | e.g., for thrombosis prevention | Inhibits uric acid excretion |
Beta-blockers | Metoprolol, atenolol, bisoprolol | Can slightly raise uric acid |
ACE inhibitors | Enalapril, ramipril | Slight increase possible |
ARBs (sartans) | Losartan lowers uric acid (!) • Others: valsartan, candesartan | Most slightly increase uric acid (exception: losartan) |
Immunosuppressants | Cyclosporine, tacrolimus | Strongly inhibit uric acid excretion |
Chemotherapy / cytostatics | Cyclophosphamide, 5-FU, etc. | Cell breakdown → major uric acid increase (tumor lysis syndrome) |
Niacin (vitamin B3) | High-dose lipid therapy | Increases uric acid production |
Tuberculosis medications | Pyrazinamide, ethambutol | Strong inhibition of uric acid excretion |
Levothyroxine (indirect if overdosed) | Thyroid hormone | Increased cell turnover → may raise uric acid |
Cyclosporine eye drops | e.g., Ikervis | Systemic use is problematic; eye drops minimal |